Additionally, due to the inclination effect, a superhydrophobic surface is relatively insensitive to variations in the roughness design. [39], In a model of young rats put on an obesogenic diet and given a hot water (tea) extract of Nelumbo Nucifera with or without 3% Taurine, but although a reduction in food intake was noted the authors suspected that this did not explain the observed weight loss. Many natural surfaces, such as those of insect wings and rice leaves, display an anisotropic configuration of micro- and nano-features to ensure the directional removal of water drops from these surfaces. [47], Mechanistically, isolated Neferine at 2-10μmol/L is able to induce apoptosis and attenuate cytokine (TGF-β1 and collagen I; up to 11% and 20% respectively) release in hepatic stellate cells in a concentration dependent manner in vitro. Potential anti-skin aging effect of Nelumbo nucifera 3 rd International Conference and Exhibition on Traditional & Alternative Medicine August 03-05, 2015 Birmingham, UK. These include being hypnotic and calming. The surfaces of both lotus Nelumbo nucifera and taro Colocasia esculenta rely on a combination of hydrophobic chemical property and the hierarchical surface structure, i.e., nanostructures on microstructures to create a surface with very high contact angle and low water roll-off angle (Ma et al., 2011). [38], Nelumbo Nucifera may be able to prevent carbohydrate absorption via amylase inhibitory potetial in vitro. It suppressed HIF-1 α expression and β-catenin. This effect was proven by the reduction of PE action in knocking down ATGs, and observed cell death in treating Bax/Bak-deficient cells with PE [139]. The Lotus Effect, discovered by Barthlott, has been investigated in the field of material sciences. [13] Hepatoprotection has been tested wth coingested Taurine (3% of water) and appear to be of larger magnitude (possible additive effects), where serum GOP and GPT were reduced more than Nelumbo Nucifera itself. 2009;461(1):41-44.19463889 48. If γsv−γsIis a lot smaller than γlv, the drop should be sitting like a marble (α = 180º). [31], Some compounds in Nelumbo appear to regulate the 5-HT3A serotonin receptors, with two compounds (methyl and ethyl-4-hydroxybenzoate) appearing to enhance a serotonin-mediated current with EC50 values of 13+/-0.5 and 16.7+/-4.2uM respectively in transfected oocytes while one (Butyl-4-hydroxybenzoate) attenuated the current, being two-fold more effective than picrotoxin at an IC50 of 18.5+/-3.1uM. These active components exhibited a stronger effect on lipolysis in visceral white adipose tissue than in subcutaneous white adipose tissue. [29] Learning deficit in rats was also attenuated in a similar degree in both groups, although not abolished. Nelumbo nucifera’s leaf, seed and flower extract showed 56%, 49%, and 54% elastase inhibition (anti-wrinkle effect) at 200 μg/ml, while adenosine indicated 26% inhibition. Nemorosone (37), a major phloroglucinol from the Cuban propolis extract, was able to sensitize Dox-resistant CRC (LoVo dox) to doxorubicin through induction of apoptosis and ROS and alteration of mitochondrial membrane potential [142]. Zhi mu clears heat and generates fluids. Inophyllum B isolated from Callophyllum inophyllum is one of the first reported NNRTI which inhibits HIV-1 RT at nanomolar concentration of IC50 = 38 nM (Patil et al., 1993). These active compounds were all monoglycosides or diglycosides containing 1→2 bonds (Figure 12.1). The roughness additionally prevents particles from sticking to the surface, because the contact area becomes too small. Neurosci Lett . The combination increased the Bax/Bcl-2 expression ratio and inhibited Akt phosphorylation. The high surface tension of pure water is crucial for the Lotus Effect. Nelumbo nucifera Gaertn (Nymphaeaceae) has long been used as a traditional herb in Chinese, Japanese, Indian, and Korean medicinal practices since prehistoric times and flourishes today as the primary form of medicine. effect of Nelumbo nucifera leaf powder. [2], In obese diabetic mice given 0.5% of their diet as Lotus root polyphenolics noted that, without affecting food intake, the polyphenolic group noted a reduction in liver weight (15% less than control) and triglyceride content (62%) without affecting hepatic cholesterol content. 6. [29] Another study using this model of amnesia and same dose of Nelumbo Nucifera, the number of Ki67-immunoreactive neurons (histological examination of in vivo neuron count) was decreased by 35.4% with scopolamine alone but increased 168.8% relative to the scopolamine group with Nelumbo;[30] this underperformed relative to 5mg/kg Galantamine (283.5%), and similar trends (benefitting, but underperforming relative to Galantamine) were noted with BDNF and DCX staining. [1] The seed embryos are sometimes referred to as Lian Zi Xin, and are a good source of Neferine relative to other plant parts. [30], It is possible Neferine mediates these effects, as it itself attenuated learning deficits from scopolamine at 1-10mg/kg oral administration in a dose-dependent manner. Anti-Angiogen ic Effect of Nelumbo nucifera Leaf. Nelumbo nucifera. [35], The isolated alkaloid Neferine may be involved in a DDAH–ADMA pathway of releasing Nitric Oxide, a pathway where Asymmetric dimethylarginine (ADMA) competitively inhibits the NOS enzyme and activation of the dimethylarginine dimethylaminohydrolase (DDAH) enzyme can convert ADMA to L-Citrulline and dimethylamine; higher activities of DDAH preserve Nitric Oxide function. However, scanty information with reference to health benefits of lotus seed as anti-inflammatory agents is available until now. [9] The mechanism appears to be related to calcium influx and phoshorylation of ERK1/2 (and secondary to that, PKC) without influencing Akt; these were thought to be due to the catechin component of Nelumbo Nucifera. If a fractal surface is created, however, this contact area is so diminished that water will not adhere anymore. All factual claims are followed by specifically-applicable references. The team includes nutrition researchers, registered Effects of Lotus (Nelumbo nucifera) Leaf Hot Water Extracts on the Quality and Stability of Eggs using Ultrasonication Treatment during Storage. In case of hyperlipidemia developed groups, feeding of Nelumbo nucifera … shark skin, fish scales, molluscs), that have been developed by these organisms to control biofouling by particulate matter, cells and microorganisms abundant in their immediate environment. Click here You JS, Lee YJ, Kim KS, Kim SH, Chang KJ (2014a) Anti‐obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre‐adipocytes and rats fed a high‐fat diet. We have a strict editorial process. Liensinine perchlorate (29), an isoquinoline alkaloid obtained from Nelumbo nucifera, was reported to have inhibitory effects on colony-forming ability of CRC cells without any significant toxicity on normal colorectal epithelial cells. The coating treatment did not diminish the bactericidal activity of the wing surface, with the attached cells being mechanically ruptured by the action of the particular surface nanopattern upon direct contact. Examine.com is intended to be used for educational and information purposes only. It induced ROS through inhibition of superoxide dismutase 3. Conditions Hair: Many conditioners contain nelumbo nucifera extracts. Apply a conditioner containing nelumbo nucifera to offer your hair that natural shine and relief from split ends. Ordinary surfaces have an inclination angle much higher than this. Protective effect of Nelumbo nucifera (Gaertn.) Je nach Dosierung können beruhigende Effekte eintreten, welche ihr euch bei Einschlafproblemen zu nutze machen könnt. A methanol extract of the stamens of Nelumbo nucifera Gaertn. If the β-AR activity of mouse adipose tissue is higher in visceral than subcutaneous tissue, as in the case of the human,20,21 then it follows that the lipolytic activity of the compounds isolated from NN may be dependent upon the β-AR’s signaling pathway. In East Asia, both P. persica flowers and N. nucifera leaves are traditionally used for therapeutic purposes and consumed as teas for weight loss. gently regulates blood stasis, has a mild effect on stopping bleeding. Recently, the naturally nanopatterned surfaces of Psaltoda claripennis cicada wings were demonstrated to kill bacteria on contact based solely on their physical surface structure (Pogodin et al., 2013). dietitians, physicians, and pharmacists. Berryhill, ... R. Tanoue, in Encyclopedia of Human Behavior (Second Edition), 2012. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. [39], An ethanolic extract of Lotus Leaf at 25-150mcg/mL was able to stimulate pancreatic β-cells under the influence of glucose to release glucose, with maximal efficacy at 50-100mcg/mL. So if … [28] In vitro, Nuciferine was found to inhibit aromatase with and IC50 of 2.12mM, with 5mmol inhibiting 90% of the activity of recombinant CYP1A2 in vitro. Magisetty Obulesu, in Alzheimer's Disease Theranostics, 2019, Plants are the richest source of pivotal therapeutic compounds that significantly contribute to human health in manifold ways.16 Despite the discovery and extensive research conducted on these compounds, there are several compounds to be discovered and utilized.16 Neferine, a bisbenzylisoquinoline alkaloid constituent of lotus (Nelumbo nucifera) plant which plays an essential role in multifarious disease therapeutics, offers significant cytoprotective efficacy in the treatment of AD.16 It has been found to show neuroprotective efficacy through autophagy.16,17 To detect neferine as the potential inhibitory compound of butyrylcholinesterase, high performance liquid chromatography (HPLC) ultraviolet analysis assisted electron spray ionization ion trap time of flight spectrometry was employed.16,18 In another study, embryo extract of N. nucifera exhibited significant inhibitory effect on β-site amyloid precursor protein cleaving enzyme-1 (BACE-1), acetylcholine esterase (AChE), and butyrylcholinesterase (BChE).16,19 Neferine nanoparticles also showed enhanced efficacy of neferine to cure diseases like malaria.16,20, Panoply of data reveals that robust antioxidant, antiglucosidase, and anticholinesterase activities of methanolic extracts and chloroform fractions of Buchanania axillaris, Hemidesmus indicus, and Rus mysorensis significantly ameliorate AD and T2D pathology.2 Mounting evidence suggests a substantial pathological link between T2D pathology and AD and T2D doubles the AD risk.2,5, M.E. reduced not only the frequency of defecation, wetness of fecal dropping and PGE2 induced enteropooling but also the propulsive Jay Trivedi, ... Debashis Mitra, in New Look to Phytomedicine, 2019. We examined the effect of NNE on digestive enzyme activity, … [44], One study that isolated betulinic acid from a methanolic extract of Nelumbo Nucifera noted that 50-100mg/kg oral administration of Betulinic acid was equally effective against a serotonin or carrageenin-induced edema test (inflammation resulting in edema) when compared to the active controls of phenylbutazone and dexamethasone. Peiminine (PE, 30), a steroidal alkaloid obtained from the bulbs of Fritillaria thunbergii, showed a significant inhibition of HCT-116 CRC cells through induction of apoptosis and autophagy. Moreover, it has to be protected from cold temperatures. INCI Nelumbo Nucifera Flower Extract: Der Inhaltsstoff Nelumbo Nucifera Flower Extract ist ein Wirkstoff pflanzlichen Ursprungs. He found that lotus leaves were covered by a microrelief, consisting of epicuticular wax crystalloids. The self-cleaning (dynamic) component of wettability is also affected by the specific surface morphology, where ordering of triple contact lines can modify the adhesive/repelling affinities of the surface (Sun et al., 2011). Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. ~ Journal of E3"I-INO- PHARMACOLOGY ELSEVIER Journal of Ethnopharmacology 58 (1997) 207 213 Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats P u l o k K . Even more interesting are examples where architecture alone, independent of the chemistry, is responsible for the bactericidal activity of the surface. Furthermore, it was effective in animal models with no toxicity on vital organs [138]. This means that nanoparticles have to sit on microparticles, a concept that is not easy to realize under practical conditions. Protein products isolated from various plants such as GAP31 from Gelonium multiflorum (Li et al., 2010), MAP30 and MRK29 from Momordica charantia (Lee-Huang et al., 1995) acts as NNRTIs at significantly low concentration. [4], One rat study feeding 100-800mg/kg Nelumbo Nucifera after physical injury to the endothelium (balloon injury) was able to inhibit ERK1/2 and JNK1/2, which suppressed MMP2 and MMP9 release. Nelumbo Nucifera Flower Extract gilt als empfehlenswert. The very high contact angle achieved on the lotus leaf (more than 160º, compared to contact angles of 40–60º on ordinary plant leaves) results in the formation of a ball-shaped water droplet. In fact, cicada wings were able to repel nor resist attachment by Pseudomonas aeruginosa cells (Ivanova et al., 2012). Abstract : Skin, which covers the entire outer surface of the body, is the … The sacred lotus (Nelumbo nucifera) - phytochemical and therapeutic profile, Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: A possible molecular mechanism, Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera, Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera, Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Nelumbo Nucifera medicine then it may not be safe to drive a vehicle or operate heavy machinery. To ensure the effect was indeed exclusively associated with surface topography, the surface of the wing was coated with a very thin gold film (~10 nm), which obscured the original surface chemistry without altering the morphology. This has not yet been achieved in real physical systems. Some of these compounds lead to improved memory performance in animals including methylene blue (a diaminophenothiazine drug) and others that are found in nature, including neferine (from Nelumbo nucifera seeds), Marapuama extract (from a type of wood in the Amazon), Ficus religiosa Linn (from a fig tree), Murraya koenigii leaves, Asparagus recemosus, and Bacopa monniera (a perennial herb). Lotus (Nelumbo) is a highly valued plant with a long history for vegetable, ornamental, and medicinal use. So we investigate the pharmacological mechanism of the anti-obesity effect of Nelumbo nucifera leaves extract (NNE). One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Known as East Indian lotus lotus lotusroot Oriental lotus sacred lotus. Furthermore, procyanidins (oligomers of catechins) exhibited lipolytic effects in 3T3-L1 adipocytes, although the monomers had no effect upon lipolysis.17 Collectively, the flavonoids were certainly shown to be responsible for the regulation of adipocyte function.18,19, Figure 12.1. [2], Bisbenzylisoquinoline Alkaloids (Nelumboferine, Nelumborine A, Nelumborine B)[3][4] and the 'main' bioactive of Nelumbo Nucifera, Neferine[3][5] as well as the structurally related Linesinine and Isolinesinine compounds[3][5], Aporphine alkaloids such as nuciferine and nornuciferine (not to be confused with neferine) and N-methylasimilobine,[6] as well as 2-Hydroxy-1-methoxyaporphin[7], Alkyl 4-hydroxybenzoates (methyl-, ethyl-, propryl- and butyl-)[8], The polphenolic catechin[9] and a content of EGCG, sometimes seen as the most potent of the four green tea catechins;[10] these can be found in the seed pod as Procyanidin C1[11][12] and the roots contain Procyanidins of the B class[13], Quercetin[14] and its 3-O-β-D-glucuronide glycoside[15] at 25-30% in flowers but 67.25-90.66% of leaf and seed total flavanoids, Isorhamnetin at 0.35-8.86% (outlier at 11.69%) total flavanoids[16], Myrictein and its 3-O-galactoside, 3-O-glucuronide, and 3-O-glucoside at 2.5-15.87% of total flavanoids (highest in flower stalk )[16], Kaempferol and its glycoside at 5.44-19.26% (except in flowers where it reaches 63% total flavanoids)[16], Diosmetin[17] at 0.21-6.36% total flavanoids (outlier at 11.31% in leaf stalks)[16], Syringetin at 0.97-2.64% total flavanoids, absent in leaves[16], 2α,24-diacetoxy-3β-hydroxyolean-12-en-28-oic acid[19], Hyptatic acid-A (2α,3β,24-trihydroxyolean-12-en-28-oic acid)[19], Hyperoside, a minor component of Hypericum Perforatum[21][15] as well as Astragalin, from Astragalus Membranaceus[21], The triterpenoic ester urs-12-en-3beta-O-9E,12E-octadecadienoate[23], LPPS, a fragment of polysaccharides divided into F1 and F2; all anti-inflammatory[24]. 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